Lymphocytes Are Pretty Important Cells - Here's How They Protect You (2024)

A lymphocyte is part of your immune system. Lymphocytes are small white blood cells that actually play an outsized role in defending your body from disease.

Your body's immune system protects you from various invaders (such as bacteria and viruses) that can cause you harm. Lymphocytes' role in this is to fight infections by producing antibodies, which are chemicals that help your body stop and then remove foreign invaders such as bacteria, viruses, fungi, parasites, and toxic chemicals.

Lymphocytes Are Pretty Important Cells - Here's How They Protect You (1)

Lymphocytes also kill cells in your body that are infected with a pathogen, and release chemicals to warn other cells of the danger. This process enables you to fight off infections and other dangers.

Lymphocytes move around your body through the lymphatic system, which is part of the circulatory system. Lymph vessels carry clear fluid, including lymphocytes and other white blood cells, throughout your body to fight infection.

Although there's some evidence that one type of lymphocytemay attack and destroy the infectious agent directly, for the most part lymphocytes leave that task to other types of white blood cells, including phagocytes. (Phagocytes work by actually swallowing and absorbing invaders that your body views as a threat, such as bacteria and small particles.)

There are two main types of lymphocytes: T cells and B cells. Each has a specific role to play in your health and in how your body fights disease. Read on to learn more about them.

What Are T Cell Lymphocytes?

T cell lymphocytes' job is to continually scan and monitor your cells for infection and the risk of infection. This goes on without you realizing it's happening inside your body.

The "T" in T cell stands for thymus, the small gland in your chest where T cells go to mature after they're manufactured by your bone marrow, and before they're sent out to patrol your body.

When a lymphocyte spots a cell that's been infected with bacteria or a virus, the lymphocyte will proceed to kill the cell. It also will actually remember the infectious agent, so it can act faster the next time it encounters the same infectious problem. This enables your immune system to identify and fight repeat infections more quickly.

These T cell lymphocytes also kill cancer cells, which is why one promising approach to cancer treatment (known as CAR-T therapy) involves isolating, multiplying and then using a patient's own T cells to fight a particular cancer. In addition, there's some evidence that T cell lymphocytes also can protect you from bacteria by actually capturing and killing the bacteria in question.

What Are B Cell Lymphocytes?

B cell lymphocytes don't attack and kill cells, viruses or bacteria themselves. Instead, they manufacture proteins called antibodies that actually stick to the surface of invaders, disabling those invaders and spotlighting them for clean up by other parts of your immune system.

The "B" in B cell lymphocytes stands for the bursa of Fabricius, a specialized organ in birds where B cells originally were discovered. Humans do not have this organ.

Although each B cell only produces one specific antibody, your body's huge number ofB-cells collectively recognize an almost unlimited number of intruders and produce a tremendous variety of antibodies to fight them.

Like T cell lymphocytes, B cell lymphocytes also are made in your bone marrow. They mature in your spleen.

A Word From Verywell

Lymphocytes don't always behave in your best interests.

Inautoimmune disease, for example, T cell lymphocytes mistakenly attack your own tissues, mistaking your cells for foreign invaders.Celiac disease, for example, involves an autoimmune attack on the lining of your small intestine. Scientists aren't certain what propels T cells to do this.

You also can develop cancer that specifically affects your lymphocytes. This type of cancer is called Hodgkin's disease or non-Hodgkin lymphoma. There are several different types of Hodgkin's disease and non-Hodgkin lymphoma, and the type you have is determined by the type of lymphocytes involved. Hodgkin's disease involves only the B cell lymphocytes, for example, while non-Hodgkin lymphoma can involve either the B cell or T cell lymphocytes.

8 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

  1. Lumen Boundless Microbiology. Phagocytes.

  2. Chemocare. The immune system: information about lymphocytes, dendritic cells, macrophages, and white blood cells.

  3. Immunity. Understanding subset diversity in T cell memory.

  4. National Cancer Institute. CAR T cells: engineering patients' immune cells to treat their cancers.

  5. Encyclopaedia Britannica. Antibody.

  6. Encyclopaedia Britannica. Lymphocyte.

  7. Jabri B, Sollid LM. T cells in celiac disease. J Immunol. 2017;198(8):3005-3014. DOI:10.4049/jimmunol.1601693

  8. Dana-Farber Cancer Institute. Non-Hodgkin lymphoma and Hodgkin lymphoma: what's the difference?

Additional Reading

Lymphocytes Are Pretty Important Cells - Here's How They Protect You (2)

By Jane Anderson
Jane Anderson is a medical journalist and an expert in celiac disease, gluten sensitivity, and the gluten-free diet.

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Lymphocytes Are Pretty Important Cells - Here's How They Protect You (2024)

FAQs

How does lymphocytes protect the body? ›

When lymphocytes identify antigens as not belonging in the body, they produce antibodies against them. This can take a few days, during which time you may feel ill. Antibodies stick to the antigens and make it easier for the other parts of the immune system to identify, destroy and remove infective agents.

What are lymphocytes and why are they important? ›

A type of immune cell that is made in the bone marrow and is found in the blood and in lymph tissue. The two main types of lymphocytes are B lymphocytes and T lymphocytes. B lymphocytes make antibodies, and T lymphocytes help kill tumor cells and help control immune responses.

Why are lymphocytes important in body defense? ›

Through receptor molecules on their surfaces, lymphocytes are able to bind antigens (foreign substances or microorganisms that the host recognizes as “nonself”) and help remove them from the body.

How do lymphocytes keep you healthy? ›

The lymph nodes and other lymphatic structures like the spleen and thymus hold special white blood cells called lymphocytes. These can rapidly multiply and release antibodies in response to bacteria, viruses, and a range of other stimuli from dead or dying cells and abnormally behaving cells such as cancer cells.

How do lymphocytes help the body quizlet? ›

lymphocytes responsible for immunological surveillance, recognizing and destroying abnormal cells when they appear in peripheral tissues. They recognize bacteria, viruses, cancer cells and foreign cells. membrane proteins on cancer cells that NK cells recognize as abnormal.

Where do lymphocytes work? ›

They occur in large numbers in the blood and lymph (the colorless fluid in the lymphatic vessels that connect the lymph nodes in the body to each other and to the bloodstream) and in lymphoid organs, such as the thymus, lymph nodes, spleen, and appendix (Figure 24-3).

What is the main function of lymphocytes? ›

Lymphocytes are white blood cells uniform in appearance but varied in function and include T, B, and natural killer cells. These cells are responsible for antibody production, direct cell-mediated killing of virus-infected and tumor cells, and regulation of the immune response.

What do lymphocytes tell you? ›

High lymphocyte blood levels often indicate your body is dealing with an infection or other inflammatory condition. A spike in your lymphocytes typically means that these white blood cells are springing into action to rid your body of an invader that can make you sick.

What level of lymphocytes is concerning? ›

But your doctor may diagnose you with lymphopenia if you have fewer than 1,500 lymphocytes per microliter. Levels higher than 4,000 may indicate a different condition, called lymphocytosis, which is most often caused by the body's response to a temporary infection or inflammatory condition.

What happens if lymphocytes are high? ›

A high lymphocyte count can point to: Infection, including bacterial, viral or other type of infection. Cancer of the blood or lymphatic system. An autoimmune disease causing ongoing, called chronic, swelling and irritation, called inflammation.

What is the lifespan of a lymphocyte? ›

Accordingly, most authorities now accept 9 to 13 days as the life span of the granulocyte1,2 and perhaps 200 days for the lymphocyte.

What are two diseases that affect the immune system? ›

Asthma, familial Mediterranean fever and Crohn's disease (inflammatory bowel disease) all result from an over-reaction of the immune system, while autoimmune polyglandular syndrome and some facets of diabetes are due to the immune system attacking 'self' cells and molecules.

Does drinking water increase lymphocytes? ›

Improves T-cell function: Every cell in the human body requires water. Drinking water helps our T-cells, a type of white blood cell called lymphocytes, that help our immune system fight germs and protect us from disease.

What cancers have low lymphocytes? ›

Cancer — especially blood or lymphatic cancers like lymphoma (such as Hodgkin's lymphoma), Kaposi sarcoma, and leukemia — can result in low lymphocyte levels. The following cancer treatments may also result in lymphocytopenia: chemotherapy. radiation therapy.

What is an alarming lymphocyte count? ›

It's typical for the lymphocyte count to rise briefly after an infection. A count much higher than 3,000 lymphocytes in a microliter of blood defines lymphocytosis in adults. In children, the number of lymphocytes for lymphocytosis varies with age. It can be as high as 8,000 lymphocytes per microliter.

Are lymphocytes responsible for immunity? ›

The T and B lymphocytes (T and B Cells) are involved in the acquired or antigen-specific immune response given that they are the only cells in the organism able to recognize and respond specifically to each antigenic epitope.

How do lymphocytes trigger an immune response? ›

Mature lymphocytes recirculate continually from the bloodstream through the peripheral or secondary lymphoid organs, returning to the bloodstream through the lymphatic vessels. Most adaptive immune responses are triggered when a recirculating T cell recognizes its specific antigen on the surface of a dendritic cell.

How does the body defend itself against infection? ›

Antibodies help the body to fight microbes or the toxins (poisons) they produce. They do this by recognising substances called antigens on the surface of the microbe, or in the chemicals they produce, which mark the microbe or toxin as being foreign. The antibodies then mark these antigens for destruction.

Is lymphocyte responsible for cellular immunity? ›

Lymphocytes, the cells competent to initiate immune responses, can be divided into two major groups: thymus-derived or T cells responsible for "cellular immunity" (e.g. delayed hypersensitivity reactions) and bursa (or bursa-equivalent) derived or B cells which produce immunoglobulin (antibody) molecules and are ...

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